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I skipped nearly all side-missions after the Headlands, and dodged as many fights in the Descent and Eridian Promontory as I could, since Lance and Guardians give a ton of XP. My last run left me at level 52 after defeating the Destroyer. The goal, then, will be to finish PT 2 as close to level 50 as possible. Old Haven - Salt Flats and beyond will be around 48-50. I like to reach New Haven at 42, and then make-sure I’m at Jaynistown in Rust Commons East at about level 46 (basically as soon as I’ve killed Krom and handed that piece to Tannis, I head over to do the “Secret Rendezvous” mission.) I usually do most of the side-missions here, but I try to reach New Haven around level 42. The same formula used in PT 1 applies here, except that we have Knoxx sitting out there with a hard starting point of level 51. Plus, completing PT 2 enables the global scaling for the main game, DLC1 and DLC 4. You’ll get a better feel for your character, and start to specialize and make your build distinct. Think of PT 1 as the introduction, and PT 2 as the real meat of the game. Playthrough 2 is really the keystone to everything subsequent. The goal here is to be done with PT 1 at about level 32 - 35, depending on how many Lance and Guardians you can skirt past at the end. 23 - 25 by the time you Seek out Tannis, 26 - 27 by the time you make the Secret Rendezvous at Jaynistown. Be sparing with your side-missions, and only do them if you need to level-up. Once at New Haven, head out to find Tannis.
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In general, do all or most of the side-missions until you defeat Sledge, and then move-on into the Dah Headlands. The only thing you need to worry about here is keeping an eye on the level of the story mission.
#Borderlands 2 dlc list in order Patch
This guide assumes the behavior of patch 1.41 is in effect. I’ve recently gone through a new playthrough, and I thought I’d share my thoughts on what I think would be the best way to access all of the DLCs while staying as close to the surrounding mission level as possible. So, there are a lot of newer people just getting into the game, and there are still a lot of ways to wind-up over or under-leveled for the area you want to play. Ideal Playthrough and Skill Points and Knoxx